Angus Russell, chief executive of the speciality pharmaceutical firm Shire, has taken advantage of a strong performance from the group recently to sell a big chunk of shares.
He offloaded 17,219 at 1,029p each, or a total of about £177,000.
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Shares in Shire have rallied strongly in the past couple of months.
The company received a boost on Tuesday when it said data from the final two Phase III trials for its Gaucher disease treatment velaglucerase alfa met expectations.
Top Director Buys
Value: £75,200
Value: $68,000
Value: £44,183
Value: £15,610
Top Director Sells
Value: £952,400
Value: £524,097
Value: £191,350
Value: £177,184
Value: £13,022
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