Unless you're a medical expert, you'll probably never have heard of ISIS Pharmaceuticals. But in five to ten years' time, assuming things go according to plan, this biotech outfit could be a household name. That's because it has developed a ground-breaking new technique called 'antisense'.
Many of today's most common diseases such as cardiovascular problems, cancer and diabetes are caused by 'bad' proteins being wrongly produced in the human body. Current drugs attack these dangerous cells, but the problem is that the side effects can be extreme, and the efficacy poor.
In contrast, antisense operates one step ahead in the DNA chain. It stops these disease-causing proteins from ever being generated by turning off the genes that encode the protein. This means none of the 'good' cells are harmed, so the side effects are far fewer, and the treatment can be tailored to each individual patient.
Subscribe to MoneyWeek
Subscribe to MoneyWeek today and get your first six magazine issues absolutely FREE
Sign up to Money Morning
Don't miss the latest investment and personal finances news, market analysis, plus money-saving tips with our free twice-daily newsletter
Don't miss the latest investment and personal finances news, market analysis, plus money-saving tips with our free twice-daily newsletter
ISIS owns 1,600 patents and currently has 19 drugs in the pipeline, most of which are being jointly developed with partners such as Genzyme, Bristol-Myers Squibb and Novartis.
ISIS Pharmaceuticals (Nasdaq: ISIS)
ISIS's first potential blockbuster drug is Mipomersen, which is aimed at cutting cholesterol levels. It's presently undergoing Phase III clinical trials; submission to the US regulator, the FDA, is set for 2010. So far the results have been very encouraging. The chief executive said in August that "key opinion leaders with whom we have shared the detailed data are thrilled".
Assuming he's right, and the FDA approves Mipomersen in 2011, shares could rocket overnight. A positive verdict would not only give the green light to this specific treatment, but would more importantly provide a huge endorsement to the whole antisense drug class. There's also no danger of patent expiries until 2023 at the earliest, and the group has $500m in net cash (or $5 a share) to fund itself for the foreseeable future.
What are the potential pitfalls? As with most early-stage biotechs, ISIS is still loss making and its success depends on one main therapeutic area. But with antisense being such a breakthrough, ISIS looks a good bet on the long-term growth in personalised medicine and ageing populations, along with being a takeover target for Big Pharma.
Recommendation: speculative BUY at $14.50 (market capitalisation $1.4bn)
Paul Hill also writes a weekly share-tipping newsletter, Precision Guided Investments
-
How working part-time in retirement could boost your pension by £87,000Easing into retirement by working a few days a week could add thousands to your pension pot. We crunch the figures to see how working part-time can boost your pension po
-
Easyjet on track for ‘record summer’ - should you invest in airline stocks?Easyjet reported headline pre-tax profits of £236 million for the three months to June 30 - up by £33 million on a year ago
